发明名称 |
TRIAZOLOPYRIDINES AND TRIAZOLOPYRIMIDINES THAT LOWER STRESS-INDUCED P-TAU |
摘要 |
In certain embodiments compounds (e.g., triazolopyrimidine(s) and/or triazolopyridine(s)) are provided that are effective to lower p-tau and/or to prevent or reduce elevation of p-tau, particularly in response to stress (e.g., elevated cortisol levels). The 5 compounds are useful in the treatment or prophylaxis of pathologies characterized by abnormal amyloid plaque and or tangle formation and/or deposition. |
申请公布号 |
WO2016134042(A2) |
申请公布日期 |
2016.08.25 |
申请号 |
WO2016US18305 |
申请日期 |
2016.02.17 |
申请人 |
BUCK INSTITUTE FOR RESEARCH ON AGING |
发明人 |
JOHN, Varghese;BREDESEN, Dale E. |
分类号 |
C07D487/04;A61K31/519;A61P25/00;A61P25/28 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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地址 |
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