| 摘要 |
The title compds. I (R=H, Ph, Ph substituted by OH, NO2, amino, thienyl, furyl, thiazollyl, cyclotexadienyl; R1=H, tBU, 2,2,2-trichloromethyl, p-nitrobenzyl, p-methoxybnezyl, diphenylmethyl; X=halo), useful as antibiotics, were prepd. Thus, 0.0mL 2,6-lutidine was mixed with 0.789g bis-α-ethyl-enamino-p-hydroxyphenylacetate-Na salt in 10mL THF and cooled at -15≦̸C, then 0.434g ethylchloroformate in 40mL THF was added. After the resulting mixt. was coolde at -40≦̸C, 1,37g p-nitrobenzyl-7-amino-3-hydroxy-3-cephem-4-carboxylate was added and stirred at 0≦̸C˜5≦̸C for 2hrs. to give 2.51g p-nitrobenzly-N,N`-(1,2-ethandilyiden)bis-7-[D-(-)-αamino-(p-hydro-xyphenyl)acetamido -3-hydroxy-3-cephem-4-carboxylate. |
