PEPTIDE ANTAGONISTS OF NEUROKININ B

摘要

Four decapeptides found to be analgesics and have antagonist activity to Neurokinin B which is also known as Neuromedin K. The decapeptides are of the following formula (I): A1-D-Pro2-His3-D4-Phe5-D-Trp6-Val7-D-Trp8-Leu9-Nle10-NH2 (I) wherein A1 and D4 are Asp or D-Asp amino acids. Also described is an HPLC separation method using piperidine.