发明名称 PREPARATION OF POLYPEPTIDES HAVING HUMAN GAMMA INTERFERON ACTIVITY
摘要 Partial sequences of human- gamma -interferon, comprising aminoacid sequences 5 to 127, 1 to 127 and 5 to 146, having biological activity. These partial sequences can be obtained by a genetic engineering process, for which purpose the appropriate DNA sequences are chemically synthesized. The DNA sequences are incorporated in hybrid plasmids, and the latter are introduced into host organisms and their expression is induced there. The biologically active polypeptides are suitable, as is human- gamma -interferon, for medicaments.
申请公布号 PH25251(A) 申请公布日期 1991.03.27
申请号 PH19480000321 申请日期 1985.04.18
申请人 HOECHST AG 发明人 JOACHIM ENGELS;MICHAEL LEINEWEBER;WOLFGANG ULMER;EUGEN UHLMANN
分类号 A61K38/21;A61K38/00;C07H21/04;C07K1/22;C07K14/52;C07K14/555;C07K14/57;C07K16/00;C12N1/20;C12N1/21;C12N15/00;C12N15/09;C12P21/02;C12R1/19 主分类号 A61K38/21
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