Antisense oligonucleotides against HSV 1, and their preparation

摘要

The invention relates to novel antisense oligonucleotides having the sequences AO1 (Herp099): +TR 5'-GCGGGGCTCCATGGGGGTCG-3' (SEQ ID NO:1) AO2 (Herp018): +TR 5'-GCAGGAGGATGCTGAGGAGG-3' (SEQ ID NO:2) AO3 (Herp002): +TR 5'-GGGGCGGGGCTCCATGGGGG-3' (SEQ ID NO:3) AO4 (Herp112): +TR 5'-GGCGGGGCTCCATGGGGGTC-3' (SEQ ID NO:4) AO5 (Herp034): +TR 5'-GGGGCTCCATGGGGGTCGTA-3' (SEQ ID NO:5) AO6 (Herp024): +TR 5'-AAGAGGTCCATTGGGTGGGG-3' (SEQ ID NO:6) AO7 (Herp028): +TR 5'-GGCCCTGCTGTTCCGTGGCG-3' (SEQ ID NO: 7). and their mixtures, homologs or modified forms, against HSV 1.