发明名称 |
1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8a beta )-6-isoquinolineamine derivatives, preparation method therefor and therapeutical use thereof |
摘要 |
PCT No. PCT/FR93/01022 Sec. 371 Date Apr. 27, 1995 Sec. 102(e) Date Apr. 27, 1995 PCT Filed Oct. 18, 1993 PCT Pub. No. WO94/10150 PCT Pub. Date May 11, 1994 <IMAGE> (I) 1,2,3,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-(8a beta )-isoquinolineamines of formula (I), wherein groups R1-R3 are as defined in the description, a method for preparing same, and therapeutical uses thereof as agents for inhibiting the biosynthesis of cholesterol, particularly epoxysqualene cyclase, which are useful as cholesterol and lipid lowering drugs, antiatheromatic and antifungal agents.
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申请公布号 |
US5580881(A) |
申请公布日期 |
1996.12.03 |
申请号 |
US19950424419 |
申请日期 |
1995.04.27 |
申请人 |
FOURNIER INDUSTRIE ET SANTE |
发明人 |
BINET, JEAN;SAMRETH, SOTH;DE FORNEL, DANIEL;BOUCHER, THIERRY;RENAUT, PATRICE |
分类号 |
A61K31/47;A61K31/472;A61P3/06;A61P9/10;A61P31/04;A61P31/10;C07D217/02;C07D217/04;C07D217/06;C07D405/06;(IPC1-7):C07D217/02 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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