EXPRESSION AND SECRETION OF HETEROLOGOUS POLYPEPTIDES FROM CAULOBACTER

摘要

DNA constructs are provided which code for a chimeric protein in which the Cterminal region correponds to the extreme C-terminal amino acids of a Caulobacter S-layer protein, fused with a heterologous polypeptide. Bacterial cells containing, or which express the DNA constructs and secrete the resulting protein are also provided. Chimeric proteins including the Cterminal amino acids of a Caulobacter S-layer protein are provided, including proteins which include antigenic epitopes of the Infectious Hematopoietic Necrosis Virus.