HETERO-TRICYCLIC COMPOUDS EXHIBITING INHIBITORY ACTIVITY AGAINST NOS

摘要

Compounds of general formula (1), tautomers, stereoisomers and optical isomers of them, and medicinally acceptable salts thereof, which exhibit excellent inhibitory activities against nNOS or iNOS, and therefore are useful as remedies for various diseases in which excessive NO or NO metabolite is believed to be concerned. In said formula, R1 is a nitrogenous hetero-tricyclic group which may be substituted with lower alkyl and/or halogeno at an arbitrary position; and R2 is optionally substituted phenyl, optionally substituted pyridyl, or a group of general formula (2), wherein R3 is lower alkyl optionally substituted with halogeno, lower alkoxy or lower alkylthio, or alternatively NHR4, SR5 or OR5, R4 being lower alkyl or nitro, and R5 being lower alkyl.