发明名称 |
PLASMINOGEN KRINGLE 4 REGION FRAGMENTS AND METHODS OF USE |
摘要 |
Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin kringle 4 region fragment. The kringle 4 region fragments generally correspond to kringle 4 structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
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申请公布号 |
WO0044391(A2) |
申请公布日期 |
2000.08.03 |
申请号 |
WO2000US02091 |
申请日期 |
2000.01.26 |
申请人 |
THE CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
SHING, YUEN, W.;O'REILLY, MICHAEL, S.;FOLKMAN, M., JUDAH |
分类号 |
C12N15/09;A61K38/00;A61K38/48;A61K48/00;A61P3/08;A61P19/02;A61P27/02;A61P35/00;C12N9/68;(IPC1-7):A61K38/00 |
主分类号 |
C12N15/09 |
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