| 摘要 |
The present invention provides methods for specifically increasing expression of MHC class I molecules in cells, and in particular, in poorly immunogenic tumor cells as well as in pathogen-infected cells. Also provided by the present invention are methods for increasing presentation of endogenous antigens onto the cell surface by MHC class I molecules, as well as methods of increasing the immunity of an animal against an antigen. The methods presented herein are useful in enhancing immune recognition of any cell infected with any pathogen, for in vitro and in vivo screening of candidate immunogene therapeutic approaches, and for enhancing the generation of antibodies to an otherwise poorly immunogenic antigen or cell. The present invention further provides methods for reducing or increasing the radiation sensitivity of a cell.
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