发明名称 |
Nitrile glycoside useful as a bioenhancer of drugs and nutrients, process of its isolation from moringa oleifera |
摘要 |
The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (-) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.
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申请公布号 |
US6858588(B2) |
申请公布日期 |
2005.02.22 |
申请号 |
US20030403814 |
申请日期 |
2003.03.31 |
申请人 |
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH |
发明人 |
KHANUJA SUMAN PREET SINGH;ARYA JAI SHANKER;TIRUPPADIRIPULIYUR RANGANATHAN SANTHA KUMAR;SAIKIA DHARMENDRA;KAUR HARPREET;SINGH MONIKA;GUPTA SUBHASH CHANDRA;SHASANY AJIT KUMAR;DAROKAR MAHENDRA PANDURANG;SRIVASTAVA SANTOSH KUMAR;GUPTA MADAN MOHAN;VERMA SUBASH CHANDRA;PAL ANIRBAN |
分类号 |
A61K31/704;A61K45/06;C07H15/06;(IPC1-7):A61K31/70;A61K31/702;C07H15/00;C07C255/32 |
主分类号 |
A61K31/704 |
代理机构 |
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代理人 |
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