发明名称 |
DEVICE AND METHOD FOR NANOPARTICLE SIZING BASED ON TIME-RESOLVED ON-CHIP MICROSCOPY |
摘要 |
A method for the label-free sizing of small, nanometer-sized objects such as particles includes a hand-held, portable holographic microscope that incorporates vapor condensation of nanolenses and time-resolved lens-free imaging. The portable device is used to generate reconstructed, time-resolved, and automatically-focused phase images of the sample field-of-view. The peak phase value for each object a function of working distance (z 2 ) and condensation time (t) is used to measure object size. The sizing accuracy has been quantified in both monodisperse and heterogeneous particle solutions, achieving an accuracy of +/- 1 1 nm for particles that range from 40 nm up to 500 nm. For larger particles, the technique still works while the accuracy roughly scales with particle size. |
申请公布号 |
WO2016118884(A1) |
申请公布日期 |
2016.07.28 |
申请号 |
WO2016US14560 |
申请日期 |
2016.01.22 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
OZCAN, AYDOGAN;MCLEOD, EUAN;DINCER, TEVFIK UMUT |
分类号 |
G01Q30/14;G01N1/10;G01N15/10;G01Q60/20 |
主分类号 |
G01Q30/14 |
代理机构 |
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