METHOD OF USING HYDROPHILIZED BACTERICIDAL POLYMERS

摘要

A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using bactericidal compositions to kill or reduce bacterial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; and/or wound dressings.

主权项

1. A method of rendering a material bactericidal comprising adding a copolymer comprising a hydrophilic first comonomer and a bactericidal second comonomer to a medium, wherein
a. the copolymer is present in or on the medium in an amount suitable to kill or significantly reduce the number of bacteria compared to an untreated medium; b. the copolymer is more bactericidal than the first comonomer alone or the bactericidal second comonomer alone; and c. the bactericidal second comonomer comprises a pyridinium-type comonomer.