AVERMECTIN AGLYCON SYNTHETASE

摘要

PROBLEM TO BE SOLVED: To obtain a DNA capable of producing an avermectin-related compound useful as a medicine, a veterinary drug or an agrochemical by encoding avermectin aglycon synthetase. SOLUTION: This DNA encodes avermectin aglycon synthetase (domain). Furthermore, the DNA has a base sequence selected from a group comprising nucleotide numbers 1-11916 and 11971-30688 of formula I and nucleotide numbers 1-14643 and 14824-31419 of formula II or the DNA encodes a polypeptide hybridized under condition which is stringent to the DNA and having avermection aglycon synthetase activity. The avermectin aglycon synthetase (domain) is obtained by culturing a transformant obtained by introducing a recombinant vector containing the DNA into a host cell which is avermectin producing microbial strain such as Streptomyces avermitilis K 2038 (FERM BP-2775) in a culture medium.