ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS TARGETED TO ANGIOTENSI N CONVERTING ENZYME mRNA AND METHODS OF USE
摘要
Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.
申请公布号
WO9915643(A3)
申请公布日期
1999.06.10
申请号
WO1998US20121
申请日期
1998.09.25
申请人
UNIVERSITY OF FLORIDA;PHILLIPS, M., IAN;MOHUCZY, DAGMARA