摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound useful as a labeling reagent for the N terminal amino group of a protein peptide and to provide a method for synthesizing the same. SOLUTION: 1-[6-(D<SB>3</SB>)Methylnicotinoyloxy]succinimide and 6-(D<SB>3</SB>)methylnicotinic acid preparation. 6-Methylnicotinic acid is deuterated to give 6-(D<SB>3</SB>)methyl nicotinic acid. 6-(D<SB>3</SB>)Methylnicotinic acid is succinimidized to give 1-[6-(D<SB>3</SB>)methylnicotinoyloxy]succinimide. 1-ä2,6-Di[(D<SB>3</SB>)methyl]nicotinoyloxy}succinimide and 2,6-di[(D<SB>3</SB>)methyl]nicotinic acid preparation. 2,6-Dimethylnicotinic acid is deuterated to give 2,6-di[(D<SB>3</SB>)methyl]nicotinic acid. 2,6-Di[(D<SB>3</SB>)methyl]nicotinic acid is succinimidized to give 1-ä2,6-di[(D<SB>3</SB>)methyl]nicotinoyloxy}succinimide. 1-(2,6-Dimethylnicotinoyloxy)succinimide preparation. COPYRIGHT: (C)2005,JPO&NCIPI
|