DIMERIC COMPOUNDS AND THEIR USE AS INHIBITORS OF NEURAMINIDASE

摘要

This invention relates to novel dimeric compounds, methods for their preparation, pharmaceutical formulations thereof, and their use as antiviral agents. The compounds are particularly useful against influenza virus. In particular the invention provides a dimeric compound which comprises two neuraminidase binding molecules attached to a spacer or linking group. Preferably the dimeric molecule comprises two neuraminidase-binding neuramin ic acid (sialic acid) or cyclopentyl or cyclohexenyl carboxylic acid derivative s covalently attached to a common spacer group. Pharmaceutical compositions an d methods of treatment, prophylaxis and diagnosis are disclosed and claimed.