Nano-recombinant fibrinogen for fibrin sealants

摘要

A fibrin-based hemostatic agent suitable for both civilian and military use is disclosed. The hemostatic agent comprises (i) nanoparticles to which a plurality of Knob-A recognition sequences are attached, and (ii) coiled-coils of recombinantly-produced human fibrinogen α and chains and the γ chain globular domain. A delivery system for the hemostatic agent also is disclosed, which additionally comprises means for delivering (i) and (ii) to a wound site. The delivery means may be a CO2 canister or a shaker jet.

主权项

1. A delivery system for a hemostatic agent, comprising:
(i) nanoparticles to which a plurality of Knob-A recognition sequences are attached, (ii) a recombinantly-produced human fibrinogen α and γ chains including coiled-coil domains of the α and γ chains and the γ chain globular domain, and (iii) means for delivering (i) and (ii) to a wound site.