| 发明名称 | Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis | ||
| 摘要 | Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance. | ||
| 申请公布号 | US9381203(B2) | 申请公布日期 | 2016.07.05 |
| 申请号 | US201414209197 | 申请日期 | 2014.03.13 |
| 申请人 | Gordon Leslie B.;Kieran Mark W.;Kleinman Monica E. | 发明人 | Gordon Leslie B.;Kieran Mark W.;Kleinman Monica E. |
| 分类号 | A61K31/44;A61K31/675;A61K31/21;A61K31/4545;A61K31/22;A61K31/436;A61K45/06;A61K31/55;A61K31/663 | 主分类号 | A61K31/44 |
| 代理机构 | JMB Davis Ben-David | 代理人 | JMB Davis Ben-David |
| 主权项 | 1. A method for treating Hutchinson-Gilford Progeria Syndrome, arteriosclerosis, or atherosclerosis, the method comprising: administering to a patient in need of such treatment a therapeutically effective dose of at least four active ingredients comprising: a farnesyltransferase inhibitor (FTI);a statin;an aminobisphosphonate; andan mTOR inhibitor, wherein the mTOR inhibitor is everolimus. | ||
| 地址 | Foxboro MA US | ||