| 摘要 |
PURPOSE:To obtain oligopeptide important as an intermediate for synthesizing peptide industrially advantageously, by subjecting a beta-lactam compound to hydrogenolysis in the presence of a palladium catalyst. CONSTITUTION:In the presence of a palladium catalyst (e.g., palladium black), a beta-lactam compound (e.g., a compound shown by the formula II) shown by the formula I(Ar is aromatic group; Ari<1> is aromatic group; R<1> is H, alkyl, aryl; R<2> is alkyl or aryl; X is azide, etc.) is subjected to hydrogenolysis to give the desired oligopeptide shown by the formula III[Y is -OR<4>, -NR2<4>, etc. (R<4> is H, substituted or unsubstituted alkyl, etc.); n is 1-4]. The reaction can be carried out using an ordinary organic solvent (e.g., methanol), is advanced smoothly at 0-150 deg.C, preferably at room temperature -100 deg.C, and isolation and purification are easy. |
