发明名称 PRODUCTION OF FOLIC ACID COMPOSITION POWDER HAVING IMPROVED FLUIDITY
摘要 PURPOSE:To obtain the title compound having improved fluidity, miscibility with other agent and storage stability and useful as a raw material for the direct tableting of tablet, etc., or an additive for food or feed, by spray-drying a dispersion of folic acid powder, wherein a part of folic acid is present in dissolved state. CONSTITUTION:A folic acid composition powder is produced by spray-drying a liquid dispersion of folic acid powder, wherein a part of the folic acid is dissolved in the liquid. The solvent used in the dispersion is water, methanol, acetone, etc., and the amount of the folic acid powder is about 30-100pts.wt., preferably 40-60pts.wt. per 100pts.wt. of the solvent. The particle diameter of the folic acid powder is <=150mum, preferably <=50mum.
申请公布号 JPH01151518(A) 申请公布日期 1989.06.14
申请号 JP19870310526 申请日期 1987.12.08
申请人 TAKEDA CHEM IND LTD 发明人 IZUMIHARA SEIJI;YOKOTA KUNIHIKO;KAKIGUCHI YOSHITOMI
分类号 A23L33/15;A61K9/14;A61K9/20;A61K31/495;C07D475/04 主分类号 A23L33/15
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