| 摘要 |
PURPOSE:To obtain a vascular embolic agent, excellent in the safety such as neither adverse side effect nor danger caused by organic solvents and suitably usable in intravascular operation. CONSTITUTION:This vascular embolic agent comprises an aqueous solution containing a heat-sensitive polymeric compound, constituted of at least one recurring unit of an N-substituted (meth)acrylamide represented by the formula (R<1> is H or methyl; R<2> is H, an alkyl or an alkoxyalkyl; R<3> is an alkyl or an alkoxvalkyl) and having a molecular weight corresponding to 0.01-6.0dl/g intrinsic viscosity [eta] in a tetrahydrofuran solution at 27 deg.C and 10-37 deg.C transition temperature in water at 0.5-50wt.% concentration. A homopolymer of the N- substituted (meth)acrylamide, a copolymer of two or more thereof and a copolymer of the N-substituted (meth)acrylamide and other monomers are cited as the heat-sensitive polymeric compound. The vascular embolic agent is capable of emerging from a catheter, thereby increasing the temperature, convertible into a solid form and blocking blood vessels.
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