发明名称 | Dry powder drug delivery system and methods | ||
摘要 | A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, endocrine disease such as diabetes and/or obesity. | ||
申请公布号 | US9358352(B2) | 申请公布日期 | 2016.06.07 |
申请号 | US201113702024 | 申请日期 | 2011.06.21 |
申请人 | MannKind Corporation | 发明人 | Smutney Chad C.;Adamo Benoit;Polidoro John M.;Kinsey P. Spencer;Overfield Dennis;Sahi Carl;Billings Christine;Marino Mark T. |
分类号 | A61M15/00;A61M11/06 | 主分类号 | A61M15/00 |
代理机构 | K&L Gates LLP | 代理人 | K&L Gates LLP ;Cullman Louis C.;Winn Robert W. |
主权项 | 1. A dry powder inhaler comprising: a) a mouthpiece; b) a housing comprising a cartridge-mounting area and a cartridge, the cartridge comprising a movable container having a dry powder, the container configured to move with respect to the cartridge and the cartridge configured to form a flow path between one or more inlet ports and one or more dispensing ports within the housing; and c) at least one rigid air conduit; wherein the rigid air conduit is configured so that the dry powder inhaler emits greater than about 75% of the dry powder from the container oriented in the container housing as powder particles in a single inhalation, and the powder particles emitted have a volumetric median geometric diameter of less than about 5 microns when the single inhalation through the mouthpiece generates a peak inspiratory pressure of about 2 kPa within two seconds. | ||
地址 | Valencia CA US |