发明名称 |
Process for the production of alpha-tocopherol esters |
摘要 |
<p>Preparation of alpha -tocopherol ester compounds (I) involves reacting a hydroquinone ester (II) with an allyl alcohol derivative (III) in presence of a zinc halide and an acid. Preparation of alpha -tocopherol esters (or derivatives or homologues) of formula (I) involves reacting a hydroquinone mono- (sic) or diester of formula (II) with an allyl alcohol derivative of formula (III) in presence of a zinc halide and a protonic acid at 25-100 degrees C. R1, R2 = optionally unsaturated 1-20C alkyl; R3-R5 = H or 1-3C alkyl; n = 0-5; Q = -C(Me)=CH-CH2L or -C(Me)(L')-CH=CH2; L = OH, halo, acetoxy, MeSO2O, EtSO2O, PhSO2O or toluenesulfonyl; L' = OH, halo or acetoxy.</p> |
申请公布号 |
IN185169(B) |
申请公布日期 |
2000.12.02 |
申请号 |
IN2182CA1998 |
申请日期 |
1998.12.16 |
申请人 |
DEGUSSA HULS AKTIENGESELLSCHAFT |
发明人 |
KRILL, STEFFEN, DR.;HUBNER, FRANK, DR.;HAHN, RAINER, DR.;WEIGEL HORST;HUTHMACHER, KLAUS, DR. |
分类号 |
C07B61/00;C07D311/72;(IPC1-7):A61K31/34;C07D307/78 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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