发明名称 |
BIOTIN CONJUGATES OF ANALYTES CONTAINING AMINO, HYDROXYL, OR THIOL FUNCTIONAL GROUPS FOR USE IN IMMUNODIAGNOSTIC ASSAYS |
摘要 |
The present disclosure provides a compound having Formula I:;;or a pharmaceutically acceptable salt of hydrate thereof, wherein R1, A, m, and n are as described herein, for use in conducting immunodiagnostic assays for accurately measuring concentrations of circulating vitamin D, as well as for thyroxine and related analytes, estrogen and related analytes, and testosterone and related analytes. |
申请公布号 |
US2016161473(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
US201414563691 |
申请日期 |
2014.12.08 |
申请人 |
Calbiotech, Inc. |
发明人 |
YOHANNES Yonas |
分类号 |
G01N33/543;G01N33/74;G01N33/78;C07D495/04;G01N33/82 |
主分类号 |
G01N33/543 |
代理机构 |
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代理人 |
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主权项 |
1. A compound having Formula I:or a pharmaceutically acceptable salt or hydrate thereof, wherein:
A is —(CH2)q—, —(CH2)qO(CH2)t—, —(CH2)NR2(CH2)q—, —(CH2)S(O)u(CH2)q—, —(CH2)tC(O)NR2(CH2)t—, —(CH2)qNR2C(O)(CH2)t—, —(CH2)qNR2C(O)O(CH2)t—, —(CH2)NR2C(O)NR3(CH2)t—, or —(CH2)qNR2C(O)S(CH2)q—; R1 is vitamin D, thyroxine, estrogen or testosterone or a metabolite or derivative thereof; R2 and R3 are each independently hydrogen or (C1-C6)alkyl; m is an integer number selected from 4, 5 and 6; n is an integer number selected from 2 to 36; q is an integer number selected from 1 to 12; t is an integer number selected from 0 to 12; and u is an integer number selected from 0, 1 and 2. |
地址 |
Spring Valley CA US |