| 发明名称 |
TREATMENT OF ADIPONECTIN (ADIPOQ) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO AN ADIPONECTIN (ADIPOQ) |
| 摘要 |
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Adiponectin (ADIPOQ), in particular, by targeting natural antisense polynucleotides of an Adiponectin (ADIPOQ). The invention also relates to the identification of these antisaese oligonucleotides and their use in treating diseases and disorders associated with the expression of Adiponectins (ADIPOQ)s. |
| 申请公布号 |
US2016168568(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201615050577 |
申请日期 |
2016.02.23 |
| 申请人 |
CuRNA, Inc. |
发明人 |
COLLARD Joseph;Khorkova Sherman Olga |
| 分类号 |
C12N15/113;C12Q1/68 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of upregulating a function of and/or the expression of an Adiponectin (ADIPOR2) polynucleotide in patient cells or tissues in vivo or in vitro comprising: contacting said cells or tissues with at least one antisense oligonucleotide of 10 to 30 nucleotides in length that targets and specifically hybridizes to a region of a natural antisense oligonucleotide of the Adiponectin (ADIPOR2) polynucleotide; thereby upregulating a function of and/or the expression of the Adiponectin (ADIPOR2) polynucleotide in patient cells or tissues in vive or in vitro. |
| 地址 |
Miami FL US |
