| 主权项 |
1. A compound of Formula I: or a pharmaceutically-acceptable salt thereof; wherein:
Y is N;Z is NR3R4, halo, H, OH, alkyl, alkyloxy, or haloalkyl;R1a is benzyl or phenyl, wherein said benzyl or phenyl is optionally substituted with one or two OH, —NR3R4, —C(═O)NR6R7, —CN, NO2—C(═O)OH, —C(═O)O-alkyl, (C1-C4)alkyl, haloalkyl or haloaryl;R2 is C1-C6 alkyl or C4-C7 cycloalkyl, wherein said alkyl or said cycloalkyl is optionally substituted with mono- or di-alkoxy, mono- or di-halophenyl, mono- or di-(C1-4)alkoxy phenyl, mono- or di-(C1-4)alkyl phenyl, perhalo(C1-4)alkyl phenyl, carboxyl, tert-butyl carboxyl, phosphoryl, (C1-6)alkyl, (C4-7)cycloalkyl, indolyl, isoindolyl, pyridyl, naphthyl, pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, furyl, thienyl, or alkylmorpholino;R3 and R4 are independently H, C1-C6 alkyl, tert-butyloxycarbonyl, morpholino(C1-C4)alkyl, carboxy(C1-C3)alkyl, (C1-C4)alkoxycarbonyl(C1-C3)alkyl, aryl, heteroaryl, aryloxy, heterocycle, cycloalkyl, alkenyl with the proviso that the double bond of the alkenyl is not present at the carbon atom that is directly linked to N, alkynyl with the proviso that the triple bond of the alkynyl is not present at the carbon atom that is directly linked to N, perfluoroalkyl, —S(O)2alkyl, —S(O)2aryl, —(C═O)heteroaryl, —(C═O)aryl, —(C═O)(C1-C6) alkyl, —(C═O)cycloalkyl, —(C═O)heterocycle, alkyl-heterocycle, aralkyl, arylalkenyl, —CON R6R7, —SO2R6R7, arylalkoxyalkyl, arylalkylalkoxy, heteroarylalkylalkoxy, aryloxyalkyl, heteroaryloxyalkyl, aryloxyaryl, aryloxyheteroaryl, alkylaryloxyaryl, alkylaryloxyheteroaryl, alkylaryloxyalkyamine, alkoxycarbonyl, aryloxycarbonyl, or heteroaryloxycarbonyl;R6 and R7 are independently H, alkyl, aryl, heteroaryl, alkylaryl, arylalkyl, heteroarylalkyl, or alkylheteroaryl;provided the compound is not 1-tert-butyl-3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine. |
