| 主权项 |
1. A process for the preparation of crystalline form IV of posaconazole comprising the steps of:
(a) providing a suspension or dispersion of:
(i) posaconazole, wherein posaconazole is selected from crystalline form III of posaconazole and(ii) methanol and (b) slurrying the suspension or dispersion at a temperature of 20-30° C.; (c) adding water to the suspension or dispersion, (d) adding posaconazole form IV seed crystals to the suspension or dispersion, (e) slurrying the suspension or dispersion at 40-60° C. until the solvent-mediated solid state transformation to posaconazole form IV is complete, (f) cooling the suspension or dispersion to a temperature of 20-30° C., (g) isolating form IV of posaconazole and (h) drying form IV of posaconazole. |
