| 摘要 |
The present invention is directed to benzoimidazole compounds of the formula:;;and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity. |
| 主权项 |
1. A compound having PHD inhibitor activity of the formula (I): wherein: n is 2-4; each R1 is independently selected from: H, halo, —C1-4alkyl, —C1-4perhaloalkyl, trifluoroC1-4alkoxy, —NO2, —CN, —OC1-4alkyl, —S—Rc, —SO2—Rc and —NRaRb; Ra and Rb are each independently H; Rc is phenyl optionally substituted with Rd; each Rd is independently selected from the group consisting of: —H, halo, —C1-4alkyl or —C1-4perhaloalkyl, trifluoroC1-4alkoxy, and —OC1-4alkyl; R2 and R3 are selected from: H, —CF3, or C1-3alkyl; and each Z is C and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. |
