COMBINATORIAL LIBRARY WITH PARTICLE CLASSES THAT CAN BE DISTINGUISHED BY TWO FEATURES E.G. SIZE, DENSITY, COLOR, ETC.

摘要

The invention relates to a method of identifying one or more substances having affinity for a given target, comprising providing a set of particle classes, each said particle class being distinguishable from another class by at least one property. The particles belonging to one and the same class may have another property that distinguishes them, e.g. different densities, thus forming sub-classes. To each unique sub-class a number of unique ligands can be attached to sets of particles forming further sub-classes. A plurality of sub-classes is combined to form at least one mixture. The mixtures are distributed in separate vessels and exposed to said substance. All target substances not having bound to any candidate substance are washed away, and it is determined to which particle sub-class(es) said target substance actually has (have) bound.