| 摘要 |
PROBLEM TO BE SOLVED: To make it possible to sustain antimicrobial activity for a long period by producing an antimicrobial urethral catheterization catheter so as to satisfy the required characteristics at the time of actual use in medical practice of specific conditions. SOLUTION: The urethral catheterization catheter to be indwelt in the living body is subjected to manipulation of making extraction for 24 hours at 37 deg.C with a physiological salt solution of 2.5 ml per 1 cm2 of its surface area repetitively 7 times and is washed with water and dried each time, following which the catheter is subjected to EOG sterilization. The antimicrobial urethral catheterization catheter subjected to the EOG sterilization is immersed at a ratio of 5 ml/cm2 in a Pseudomonas aeruginosa suspension regulated to a concentration of the number of living bacteria of 1×105 pieces/ml by a Burrow's solution diluted 50 times by the physiological salt solution and is so sterilized that the number of living bacteria in the immersion liquid after shaking and culturing for 24 hours at 37 deg.C of the catheter subjected to 7 times of the extraction manipulation by the physiological salt solution is <=1×106 pieces/ml. In addition, a stage for introducing the compound bondable to an antimicrobial agent into the urethral catheterization catheter, then a stage for introducing a silver compound into the surface by an aqueous solution of a water-soluble silver compound are carried out after molding of the catheter and before drying or heat treatment. |
