发明名称 |
Process for the production of r(+)alpha-lipoic acid |
摘要 |
Process for the synthesis of R(+)alpha-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)alpha-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)alpha-lipoic acid-R(+)alpha-methylbenzylamine; c) purification by re-crystallization of the diastereoisomeric salt of R(+) alpha-lipoic acid-R(+)alpha-methylbenzylamine, in which the re-crystallization solvent consists of a mixture of non-polar/polar solvents; d) separation of the diastereoisomeric salt to obtain R(+)alpha-lipoic acid by reaction of said salt with acids selected from the group consisting of aliphatic hydroxy-carboxylic acids having 3 to 6 carbon atoms and aqueous phosphoric acid. |
申请公布号 |
AU2360302(A) |
申请公布日期 |
2002.04.22 |
申请号 |
AU20020023603 |
申请日期 |
2001.10.08 |
申请人 |
LABORATORIO CHIMICO INTERNAZIONALE S.P.A. |
发明人 |
FLAVIO VILLANI;ANTONIO NARDI;ANNIBALE SALVI;GIOVANNA FALABELLA |
分类号 |
C07B57/00;C07C319/06;C07C323/60;C07D339/04 |
主分类号 |
C07B57/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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