1-CYCLOPROPYL-7-([S,S]-2,8-DIAZABICYCLO[4,3,0]NONE-8-YL)-6- -FLUORO-1,4-DIHYDRO-8-METHOXY-4-OXO-3-QUINOLINE CARBOXYLIC ACID HYDROCHLORIDE MONOHYDRATE AND PHARMACEUTICAL COMPOSITION WITH ANTIBACTERIAL ACTIVITY

摘要

organic chemistry, pharmacy. SUBSTANCE: invention relates to the compound 1-cyclopropyl-7-([S,S]-2,8-diazabicyclo[4.3.0]none-8-yl)-6- -fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid of the formula (I) showing characteristic peak at 168,1 m. d. in 13C-NMP-spectrum and the line at angle 2&thetas; = 26.7 in roentgen diffractogram and exhibiting an antibacterial activity. Preferable form of the compound is its monohydrate crystallizing as prisms that gives the excellent properties of fluidity and friability to nonhydrate form of this compound. EFFECT: valuable antibacterial activity of compound. 4 cl, 8 dwg, 5 tbl, 8 ex