| 摘要 |
Compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof, effective in the prevention and/or treatment of infections with microbes: (1) (a) wherein R<SUB>1 </SUB>is hydrogen or straight-chain C<SUB>1-6 </SUB>alkylcarbonyl; R<SUB>2 </SUB>is hydrogen or C<SUB>1-6 </SUB>alkylcarbonyl; R<SUB>3 </SUB>is hydrogen, C<SUB>1-6 </SUB>alkyl, C<SUB>1-6 </SUB>alkylcarbonyl, C<SUB>1-6 </SUB>alkenyl, C<SUB>2-6 </SUB>alkenylcarbonyl, C<SUB>2-6 </SUB>alkynyl, or an Ar-B- group (wherein Ar is aryl or a heterocyclic group; and B is C<SUB>1-6 </SUB>alkyl, C<SUB>1-6 </SUB>alkylcarbonyl, C<SUB>2-6 </SUB>alkenyl, C<SUB>2-6 </SUB>alkenylcarbonyl, or C<SUB>2-6 </SUB>alkynyl); R<SUB>5</SUB>, R<SUB>6</SUB>, R<SUB>7 </SUB>and R<SUB>8 </SUB>are each hydrogen, C<SUB>1-6 </SUB>alkyl, C<SUB>2-6 </SUB>alkenyl, C<SUB>2-6 </SUB>alkynyl, or an Ar-B'- group (wherein B' is C<SUB>1-6 </SUB>alkyl, C<SUB>2-6 </SUB>alkenyl, or C<SUB>2-6 </SUB>alkynyl); X is oxygen or -NR<SUB>4</SUB>- (wherein R<SUB>4 </SUB>is hydrogen, C<SUB>1-6 </SUB>alkyl or C<SUB>1-6 </SUB>alkyl which may be substituted with Ar); and R<SUB>4'</SUB> is hydrogen or a group represented by the general formula (a) (wherein R<SUB>3''</SUB> and R<SUB>4''</SUB> are each hydrogen or straight-chain or branched C<SUB>1-6 </SUB>alkylcarbonyl)
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