| 摘要 |
Novel compounds of formula <FORM:1111489/C2/1> and acid addition salts thereof where R1 is CH3 or phenyl, R2 is H, halogen, CH3 or methoxy R3 is C1- 4 alkyl or phenyl optionally substituted by halogen atoms or C1- 4 alkyl or alkoxy groups, R4 is C2- 4 alkenyl and R5 is an alkyl group substituted by a C3- 8 cycloalkyl group, aralkyl or alkenyl or R4 and R5 together with the nitrogen atom to which they are attached form a saturated or partly saturated heterocyclic ring which may contain an additional oxygen or nitrogen atom and is substituted by phenyl which may itself be substituted by halogen, hydroxy, C1- 4 alkoxy or C1- 4 alkyl and A is a straight or branched chain C2- 4 hydrocarbon group are prepared by cyclisation of a hydrazone of formula <FORM:1111489/C2/2> optionally followed by salt formation. Hydrazones of the last formula above are prepared by reacting the appropriate phenyl hydrazine with a ketone of formula <FORM:1111489/C2/3> which has been prepared for example by reaction of a phenyl acetone and a compound halogen -A-NR4.R5. Pharmaceutical compositions in conventional forms for oral, rectal and parenteral administration and having analgesic, antiphlogistic, antitussive and spasmolytic activity comprise an above novel compound and a carrier or excipient. |
