发明名称 |
Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
摘要 |
The invention provides a process for the production of compounds of the formula: <IMAGE> wherein R, R3, R4 and W are defined in the specification in which a compound of the following formula: <IMAGE> is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar aprotic solvent. The resulting compounds are useful as antibiotics.
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申请公布号 |
US5495031(A) |
申请公布日期 |
1996.02.27 |
申请号 |
US19940304913 |
申请日期 |
1994.09.13 |
申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
SUM, PHAIK-ENG;LEE, VING J.;TESTA, RAYMOND T. |
分类号 |
A61K31/16;A61K31/40;A61K31/403;A61K31/425;A61K31/428;A61K31/65;A61P31/04;C07C;C07C231/12;C07C237/26;C07C255/50;C07C255/52;C07C317/28;C07D207/16;C07D209/02;C07D211/14;C07D211/22;C07D211/26;C07D213/36;C07D213/38;C07D233/56;C07D233/64;C07D237/26;C07D249/04;C07D249/08;C07D261/08;C07D265/30;C07D277/64;C07D293/00;C07D295/12;C07D295/13;C07D295/14;C07D295/15;C07D295/22;C07D295/30;C07D307/32;(IPC1-7):C07D207/18 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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