| 发明名称 |
PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS |
| 摘要 |
The present invention describes pyridazinone compounds of formula (I) which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectively of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
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| 申请公布号 |
CA2347982(A1) |
申请公布日期 |
2000.05.04 |
| 申请号 |
CA19992347982 |
申请日期 |
1999.10.27 |
| 申请人 |
ABBOTT LABORATORIES |
发明人 |
LIU, HUAQING;KOLASA, TEODOZYJ;BASHA, ANWER;KORT, MICHAEL E.;STEWART, ANDREW O.;PATEL, MEENA V.;ROHDE, JEFFREY J.;MCCARTY, CATHERINE M.;COGHLAN, MICHAEL J.;BLACK, LAWRENCE A. |
| 分类号 |
A61K31/50;A61K31/501;A61P19/02;A61P25/04;A61P29/00;A61P35/00;C07D237/14;C07D237/16;C07D237/18;C07D237/22;C07D401/04;C07D401/06;C07D401/12;C07D403/04;C07D403/10;C07D403/12;C07D405/04;C07D405/12;C07D409/04;C07D409/06;C07D409/12;C07D413/04;C07D413/12;C07D417/06;(IPC1-7):C07D237/14 |
主分类号 |
A61K31/50 |
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