发明名称 |
Drug delivery compositions for improved stability stability of steroids. |
摘要 |
A stabilized patch device for transdermal drug delivery of steroid drugs containing a 3-keto-4-en functional group is described, wherein the patch comprises an effective amount of the steroid drug and a carrier that is free of acid functional groups. The device can further contain additives such as a penetration enhancer or excipient, so long as such additives are also free of acid functional groups. The device can be either a matrix patch or a liquid reservoir patch. In a matrix patch, the carrier is a biocompatible polymeric adhesive with which the steroid drug is intimately admixed. The adhesive is preferably an acrylic polymer or copolymer. In a liquid reservoir patch, the carrier is a controlled-viscosity composition containing a thinner or thickener. Preferred steroid drugs include certain corticosteroids and sex hormones, such as progestins and androgens. A method of stabilizing such steroid drugs during storage in transdermal patches is also disclosed. |
申请公布号 |
HK1017983(A1) |
申请公布日期 |
2004.12.24 |
申请号 |
HK19980112667 |
申请日期 |
1998.12.02 |
申请人 |
THERATECH, INC. |
发明人 |
UDAY JAIN;SRINIVASAN VENKATESHWARAN;EBERT, CHARLES, D. |
分类号 |
A61K9/70;A61K31/565;A61K31/57;A61K47/04;A61K47/10;A61K47/14;A61K47/16;A61K47/20;A61K47/30;A61K47/32;A61K47/44;A61P5/24;A61P5/38;(IPC1-7):A61K;A61F;A61P |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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