发明名称 |
DETECTION OF MEMBRANE ANDROGEN RECEPTOR (mAR) AGENTS. |
摘要 |
Disclosed are methods to detect agents that modulate a membrane androgen receptor (mAR). In one embodiment, the invention provides a method to detect and optionally identify mAR binding ligands. Oneessay according to the invention detects agents that selectively bind the mAR relative to binding to the classical intracellular androgen receptor (iAR or AR). The invention haw a wide spectrum of useful applications including providing a method of screening libraries for chemical entities that preferentially bind the mAR. |
申请公布号 |
GR1006058(B) |
申请公布日期 |
2008.09.12 |
申请号 |
GR20060100207 |
申请日期 |
2006.04.03 |
申请人 |
MEDEXIS AEVE |
发明人 |
BAKOPOULOS NIKOLAOS;ALEVIZOPOULOS KONSTANTINOS;BUCHANAN ROBERT L.;STOURNARAS CHRISTOS |
分类号 |
G01N33/52;G01N33/566;G01N33/60;G01N33/68;G01N33/74 |
主分类号 |
G01N33/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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