发明名称 |
METHOD FOR PRODUCTION OF SUGAR OXAZOLINE DERIVATIVE |
摘要 |
<p>Disclosed is a process for producing an oxazoline derivative from a non-protected sugar in a simple manner. Also disclosed is a process for producing a glycoside by utilizing the product of the aforementioned process. A sugar oxazoline derivative is synthesized in one step in an aqueous solution from a sugar having a free hemiacetalic hydroxy group and an amido group by using a haloformamidinium derivative as a dehydrating agent. A glycoside compound is produced by using the oxazoline derivative as a sugar donor and also using a sugar dehydrogenase. The method can be applied to the production of a compound having a long sugar chain, and is therefore useful for the production of a physiologically active oligosaccharide, a carrier for a drug delivery system, a surfactant, a carbohydrate-based drug, a glycopeptide, a glycoprotein, a carbohydrate polymer or the like.</p> |
申请公布号 |
EP2123663(A1) |
申请公布日期 |
2009.11.25 |
申请号 |
EP20080721612 |
申请日期 |
2008.03.07 |
申请人 |
SEIKAGAKU CORPORATION |
发明人 |
SHODA, SHINICHIRO;KOBAYASHI, ATSUSHI;NOGUCHI, MASATO;TANAKA, TOMONARI;GYAKUSHI, HIDETOSHI |
分类号 |
C07H9/06;A61K31/7008;A61K31/702;A61K31/7056;A61K31/715;A61P15/00;A61P17/02;A61P29/00;A61P35/00;A61P37/00;C08B37/00 |
主分类号 |
C07H9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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