Compositions for inhibiting immune complex formation in a subject

摘要

Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation, are described.

主权项

1. A composition comprising a pharmaceutically acceptable carrier and a polypeptide that comprises the amino acid sequence Cys-Ala-Xaa-His-Leu-Gly-Glu-Leu-Val-Trp-Cys-Thr (SEQ ID NO:8), wherein the Xaa in SEQ ID NO:8 is Trp, Tyr, or Phe, wherein administration of said composition to a subject in need thereof reduces immune complex formation in said subject, wherein the polypeptide further comprises a terminal stabilizing group at the amino-terminal end, wherein the terminal stabilizing group is a tripeptide having the amino acid sequence Xaa-Pro-Pro, wherein the Xaa in the terminal stabilizing group is any amino acid, and wherein the terminal stabilizing group facilitates survival of the polypeptide in vivo.