Derivatives of C-076 compounds.

摘要

Certain new derivatives of C-076 compounds have been isolated from the livers of animals that had been administered ivermectin and the in vitro incubation of such compounds with animal liver preparations. The compounds have the formula:
<CHEM>
in which R1 is
<CHEM>
R2 is methyl or ethyl and the 22,23 bond is saturated or (but only when R2 is ethyl) ethylenically unsaturated, or R is hydrogen, R2 is methyl or ethyl and the 22,23 bond is saturated.
<??>The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.