Monoclonal antibody and method of manufacturing hybridoma producing the same

摘要

A monoclonal antibody specific to a sugar chain containing N-glycolylneuraminic acid and has an ability to bind at least to N-glycolyl GM2 ganglioside, and producing methods of a hybridomas which produce the monoclonal antibodies are disclosed. The antibodies are extremely useful for clarification of carcinogenesis mechanism, cancer diagnosis and therapy. The hybridomas are manufactured by using an animal with autoimmune disease.