发明名称 |
Thrombin inhibitors based on the amino acid sequence of hirudin |
摘要 |
A thrombin inhibitor comprising a first bulky hydrophobic portion interacting with the catalytic site of thrombin responsible for proteolysis and a second portion at least maintaining the hydrophobic and acidic character of amino acids 55 to 60 of native hirudin at the C-terminal non-catalytic region of N-acetyl-hirudin45-65. Between the first and second portions is a divalent linker moiety having a chain length of at least 10 carbon atoms. Connecting the first bulky hydrophobic portion and the linker is a peptidomimetic bond. Preferably, the bulky hydrophobic portion comprises at least one amino acid of D-configuration. The compounds are useful in the treatment of thrombotic disorders. |
申请公布号 |
AU4934996(A) |
申请公布日期 |
1996.10.08 |
申请号 |
AU19960049349 |
申请日期 |
1996.03.18 |
申请人 |
THE NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
JOHN DIMAIO |
分类号 |
A61K38/00;A61P7/02;C07K7/06;C07K14/815 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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