NEW CARBAPENEM DERIVATIVES

摘要

New carbapenem derivatives of general formula (I) wherein R1 represents hydrogen or methyl; one of R2, R3, R4 and R5 represents a bond at the 2position of the carbapenem ring and other three of them represent each hydrogen, halogen, nitro, cyano, alkyl, cycloalkyl, alkylthio, alkenyl, formyl, alkylcarbonyl, alkoxycarbonyl, aminosulfonyl, arylcarbonyl, aryl, carbamoyl, N-(lower alkyl)carbamoyl, N,N-di(lower alkyl)aminocarbonyl, lower alkoxyiminomethyl or hydroxyiminomethyl; R6 is not present or represents alkyl, cycloalkyl or alkenyl; R is absent or represents hydrogen or a group hydrolyzable in vivo, provided when R6 is absent, R represents hydrogen or a group hydrolyzable in vivo and when R6 is present, R is absent and an inner salt is formed. The compounds have patent antimicrobial activities against meticillin-resistant Staphylococcus aureus, penicillin-resistant pneumococcus, enterococcus, influenza virus and .beta.-lactamase-producing microbes, and are highly resistant to DHP-1.