摘要 |
This invention includes fusion proteins comprising a bacterial ADP-ribosylating exotoxin (bARE), or a variant or portion thereof, fused to a STa exotoxin, or a portion or variant thereof. Optionally, the exotoxins are fused via a peptide linker. The invention also includes compositions formulated for transcutaneous immunizations and/or induction of an immune response by epicutaneous administration comprising an effective amount of a fusion protein comprising a bacterial ADP-ribosylating exotoxin fused to a STa exotoxin. Optionally, the exotoxins are fused via a peptide linker. |
申请人 |
IOMAI CORPORATION;TIAN, JIAN-HUI;GLENN, GREGORY, M.;ELLINGSWORTH, LARRY, R. |
发明人 |
TIAN, JIAN-HUI;GLENN, GREGORY, M.;ELLINGSWORTH, LARRY, R. |