发明名称 |
ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OFPYRROLIZINES, AND THEIR PHARMACEUTICAL USE |
摘要 |
The present invention relates to compounds of the formula I <see formula I> in which one of the radicals R8 and R9 is a hydrogen atom or an alkyl group and the other is hydroxyl, alkoxy or acyloxy or where R8 and R9, together with the carbon atom to which they are bonded, are a carbonyl group and the radicals R1 to R7 have the meanings indicated in the description. The compounds inhibit the release of various mediators of the arachidonic acid cascade and can thus be used for the prevention of allergically induced disorders or for the treatment of disorders of the rheumatic type.
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申请公布号 |
CA2391871(C) |
申请公布日期 |
2009.01.27 |
申请号 |
CA19992391871 |
申请日期 |
1999.11.23 |
申请人 |
MERCKLE G.M.B.H. |
发明人 |
LAUFER, STEFAN;TOLLMANN, KAROLA;STRIEGEL, HANS-GUNTER |
分类号 |
C07D487/04;A61K31/407;A61P29/00;A61P37/08 |
主分类号 |
C07D487/04 |
代理机构 |
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主权项 |
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地址 |
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