| 摘要 |
The present invention relates to substituted 5-phenyl pyrimidines I, which carry a radical X in the 4-position of the pyrimidine ring, a radical Y in the 6-position of the pyrimidine ring, the radical X denoting a group of the formula NRR, ORor SR, in which R, R, independently of each other, denote hydrogen, С-С-allcyl, С-С-alkenyl, С-С-alkynyl, С-С-haloalkyl, С-С-cycloalkyl, С-С-halocycloalkyl, phenyl, or 5- or 6-membered heteroaryl or 5- or 6-membered heterocyclyl, containing 1,2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which radicals may be unsubstituted or may carry 1, 2, 3 or 4 radicals R; or the radical NRRmay also form a 5- or 6-membered optionally substituted heterocyclic ring, containing 1, 2, 3 or 4 nitrogen atoms or 1, 2 or 3 nitrogen atoms and one sulfur or oxygen atom as ring members, which are non-adjacent to the nitrogen of NRR, in which two adjacent С atoms or one N atom and one adjacent С atom can be linked by аС-С-alkylene chain and wherein the heterocyclic ring may be unsubstituted or may carry 1, 2, 3 or 4 radicals Ras defined in claim 1, Rhas one of the meanings given for Rexcept for hydrogen; the radical Y being selected from the group consisting of halogen, cyano, С-С-alkyl, С-С-alkenyl, С-С-alkynyl, С-С-cycloalkyl, С-С-alkoxy, С-С-alkenyloxy, С-С-alkynyloxy, С-С-alkylthio, і di-(С-С-alkyl)amino or С-С-alkylamino, where the alkyl, alkenyl and alkynyl radicals of Y may be substituted by halogen, cyano, nitro, С-С-аlкоху or С-С-alkoxycarbonyl; and wherein the pyrimidine radical may also carry a radical different from hydrogen, in the 2-position and wherein the phenyl ring in the 5-position of the pyrimidine ring may be unsubstituted or carry 1, 2, 3, 4 or 5 radicals L which are different from hydrogen, and the pharmaceutically acceptable salts substituted 5-phenyl pyrimidines for use in therapy, in particular in therapy or treatment of cancerous diseases. |
