| 发明名称 |
RNA DISRUPTION ASSAY FOR PREDICTING SURVIVAL |
| 摘要 |
A method for the prediction and/or prognosis of survival time of a patient suffering from cancer, comprising the steps of: a) measuring a RDA score in a tumor tissue sample comprising cellular RNA from said patient after said patient has received one or more doses of a cancer treatment; b) comparing said RDA score to one or more predetermined RNA disruption reference values; and c) providing a favorable prediction and/or prognosis of survival time for said patient when said RDA score is higher than said predetermined RNA disruption reference value; or providing an unfavorable prediction and/or prognosis of survival time for said patient when said RDA score is lower than said predetermined RNA disruption reference value, wherein the RDA score is proportional to the degree of RNA disruption. |
| 申请公布号 |
US2016237506(A1) |
申请公布日期 |
2016.08.18 |
| 申请号 |
US201415027080 |
申请日期 |
2014.10.06 |
| 申请人 |
RNA DIAGNOSTICS INC. |
发明人 |
Pritzker Kenneth;Pritzker Laura;Parissenti Amadeo Mark;Wang Xiaohui |
| 分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the prediction and/or prognosis of survival time of a patient suffering from cancer, comprising the steps of: a) measuring RNA disruption by determining an RNA disruption assay (RDA) score in a tumor tissue sample comprising cellular RNA from said patient after said patient has received one or more doses of a cancer treatment; b) comparing said RDA score to one or more predetermined RNA disruption reference values; and c) providing a favorable prediction and/or prognosis of survival time for said patient when said RDA score is higher than said predetermined RNA disruption reference value; or providing an unfavorable prediction and/or prognosis of survival time for said patient when said RDA score is lower than said predetermined RNA disruption reference value, wherein the RDA score is proportional to the degree of RNA disruption. |
| 地址 |
Toronto CA |
