发明名称 |
HETEROARYL PHENYL PYRAZOLE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS |
摘要 |
This invention relates to a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein A and R1 are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2 is (C1-C4)alkyl optionally substituted with halo, amino or an alkyl amino; R3 and R4 are each hydrogen, halo, (C1-C4)alkyl optionall y substituted with halo and the like; and X1 to X4 are each hydrogen, halo, hydroxy, (C1-C4)alk yl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.
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申请公布号 |
CA2327256(A1) |
申请公布日期 |
2001.06.03 |
申请号 |
CA20002327256 |
申请日期 |
2000.12.01 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
ANDO, KAZUO;MINICH, MARTHA LOU;CHENG, HENGMIAO;KATO, TOMOKI;LUNDY, KRISTIN MARIE;LI, JIN;BRONK, BRIAN SCOTT;SAKYA, SUBAS MAN;KAWAMURA, KIYOSHI |
分类号 |
C07D401/14;A61K31/427;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4439;A61K31/501;A61K31/506;A61P1/00;A61P1/02;A61P1/04;A61P7/00;A61P7/02;A61P7/04;A61P7/06;A61P11/06;A61P13/12;A61P15/00;A61P17/02;A61P19/00;A61P19/02;A61P19/06;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P31/12;A61P35/00;A61P43/00;C07D405/14;C07D409/14;C07D413/14;C07D417/14;(IPC1-7):C07D417/14;C07D471/04;C07D491/052;C07D403/14;A61K31/454;A61K31/47;A61K31/497;A61K31/53 |
主分类号 |
C07D401/14 |
代理机构 |
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地址 |
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